您可以对值进行排序，然后对groupby:

You can sort the values, then groupby:

a= np.sort(df.to_numpy(), axis=1)
df.groupby([a[:,0], a[:,1]], as_index=False, sort=False).first()

选项2 :如果c1, c2对很多，groupby可能会变慢.在这种情况下，我们可以分配新值并按drop_duplicates进行过滤:

Option 2: If you have a lot of pairs c1, c2, groupby can be slow. In that case, we can assign new values and filter by drop_duplicates:

a= np.sort(df.to_numpy(), axis=1) 

(df.assign(one=a[:,0], two=a[:,1])   # one and two can be changed
   .drop_duplicates(['one','two'])   # taken from above
   .reindex(df.columns, axis=1)
)