首先尝试

项目 - > DataSource然后继续，创建一个tableadapter，你的问题变得简单了。你可以尝试保存它，但保存意味着更新，插入和删除。 

https://msdn.microsoft.com/en-us/library/bb384426.aspx

 connectdb1()
            conn.Open()
            CMD = New SqlCommand(RichTextBox1.SelectedText, conn)
            DR = CMD.ExecuteReader
            ds = New DataSet()
            dtb = New DataTable("mytable")
            ds.Tables.Add(dtb)
            ds.Load(DR, LoadOption.PreserveChanges, ds.Tables(0))
            DataGridView1.DataSource = ds.Tables(0)



 Private Sub Btn_update_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Btn_update.Click
        
          
**** i need help source code for update from datagridview

    End Sub 

I will be very grateful if you want to help me for the code above

tanks,,

Try first

Project -> DataSource and then go on, create a tableadapter and your problem become easy. You can try to save it, but saving means update, insert and delete. 

https://msdn.microsoft.com/en-us/library/bb384426.aspx