如果您正在使用摇篮/ Android的工作室，你可以添加到您的摇篮配置：

If you are using Gradle/Android Studio, you can add this to your gradle configuration:

android {
....
   dexOptions {
    preDexLibraries = false
   }
}

afterEvaluate {
    tasks.matching {
        it.name.startsWith('dex')
    }.each { dx ->
        if (dx.additionalParameters == null) {
            dx.additionalParameters = []
        }
        dx.additionalParameters += '--multi-dex'

        // this is optional
        // dx.additionalParameters += "--main-dex-list=$projectDir/multidex.keep".toString()
    }
}

然后你需要添加multidex支持库罐子，位于 SDK /演员/安卓/支持/ multidex /库/库。并安装它通过从 MultiDexApplication 扩展您的应用程序，或调用 Multidex.install（）从应用程序的 attachBaseContext 方法。

Then you need to add the multidex support library jar, located in sdk/extras/android/support/multidex/library/libs. And install it either by extending your application from MultiDexApplication, or calling Multidex.install() from your application's attachBaseContext method.

有关更详细看这个博文：的 http://blog.osom.info/2014/10/multi-dex-to-rescue-from-infamous-65536.html

For more details look at this blogpost: http://blog.osom.info/2014/10/multi-dex-to-rescue-from-infamous-65536.html

更新：

下面 https://developer.android.com/tool​​s/building/multidex.html 你可以找到使用multidex有摇篮的正式方法。

Here https://developer.android.com/tools/building/multidex.html you can find the official way to use multidex with Gradle.

基本上你需要改变你的摇篮文件是这样的：

Basically you need to change your gradle file like this:

android {
   compileSdkVersion 21
   buildToolsVersion "21.1.0"

   defaultConfig {
       ...
       minSdkVersion 14
       targetSdkVersion 21
       ...

       // Enabling multidex support.
       multiDexEnabled true
   }
   ...
}

dependencies {
  compile 'com.android.support:multidex:1.0.0'
}

和设置您的应用程序类android.support.multidex.MultiDexApplication或者如果你已经有一个应用程序类，你可以覆盖attachBaseContext（）方法，并调用MultiDex.install（本），以使multidex。

And set your Application class to android.support.multidex.MultiDexApplication or if you already have an Application class you can override the attachBaseContext() method and call MultiDex.install(this) to enable multidex.