2017年4月发布了一篇文章，介绍如何从同一解决方案支持两个运行时:

There is an article published in April 2017 on how to support both runtimes from the same solution:

https://docs.microsoft.com/zh-我们/dotnet/core/porting/project-structure

它归结为两种方法:

• 在同一个项目中配置了两个框架(例如* .csproj):

用多目标.NET Core项目替换现有项目.

Replace existing projects with a multi-targeted .NET Core project.

• 每个框架都有一个单独的项目:

保留现有项目并创建.NET Core项目.

Keep existing projects and create a .NET Core project.

由于该项目支持Windows上的.NET Framework和Linux/OSX上的Mono，因此我们正在积极讨论使用pythonnet的方式.现在，我们添加了跨平台的pythonnet支持:

We are actively discussing which way to go in pythonnet, since the project supports .NET Framework on Windows and Mono on Linux/OSX. Now we are adding cross-platform pythonnet support:

https://github.com/pythonnet/pythonnet/pull/518