yes it is.

$collection->addAttributeToFilter(
    array(
        array('attribute' => 'someattribute', 'like' => 'value'),
        array('attribute' => 'otherattribute', 'like' => 'value'),
        array('attribute' => 'anotherattribute', 'like' => 'value'),
    )
);

see also in Magento Wiki