我不认为有任何可靠的方法来检测这一点（特别是在跨平台的方式）。例如，在OS X上，当你双击一个 .py 文件，它用Python启动器调试，它运行在终端，等同于手动执行。

I don't think there's any reliable way to detect this (especially in a cross-platform manner). For example on OS X, when you double-click a .py file and it tuns with "Python Launcher", it runs in a terminal, identically to if you execute it manually.

虽然可能还有其他问题，但您可以使用 py2exe 或 Platypus ，则可以让双击图标运行特定位的代码来区分（ import mycode; mycode.main（gui = True）例如）

Although it may have other issues, you could package the script up with something like py2exe or Platypus, then you can have the double-clickable icon run a specific bit of code to differentiate (import mycode; mycode.main(gui = True) for example)