您可以使用控件ClientId属性（它唯一地标识在客户端控制）和让这样的事情：

You can use ClientId property of controls (it's uniquely identifies control on the client side) and make something like that:

<asp:TextBox runat="server" ID="myTextBox" />
<asp:Button runat="server" ID="myButton" Text="click" />

<script language="javascript" type="text/javascript">
    document.getElementById("<%=myTextBox.ClientID %>").onclick = function() {
        document.getElementById("<%=myButton.ClientID %>").disabled = "disabled";
    }
</script>

也可参考此文档：
的客户端脚本ASP.NET网页，部分引用服务器控件的客户端脚本