using (SqlConnection Conn = new SqlConnection(ConfigurationManager.ConnectionStrings["ConnectionString"].ConnectionString))
{
try
{
const string SQL = "INSERT INTO [BinaryTable] ([FileName], [DateTimeUploaded], [MIME], [BinaryData]) VALUES (@FileName, @DateTimeUploaded, @MIME, @BinaryData)";
SqlCommand cmd = new SqlCommand(SQL, Conn);
cmd.Parameters.AddWithValue("@FileName", FileName.Text.Trim());
cmd.Parameters.AddWithValue("@MIME", FileToUpload.PostedFile.ContentType);

byte[] imageBytes = new byte[FileToUpload.PostedFile.InputStream.Length + 1];
FileToUpload.PostedFile.InputStream.Read(imageBytes, 0, imageBytes.Length);
cmd.Parameters.AddWithValue("@BinaryData", imageBytes);
cmd.Parameters.AddWithValue("@DateTimeUploaded", DateTime.Now);

Conn.Open();
cmd.ExecuteNonQuery();
lit_Status.Text = "<br />File successfully uploaded - thank you.<br />";
Conn.Close();
}
catch
{
Conn.Close();
}
}

http://www.dotnettutorials.com/教程/数据库/upload-files-sql-database-cs.aspx