您可以使用 ListView HitTest 方法.它返回一个 ListViewHitTestInfo 对象.
它的 SubItem 属性为您提供ListViewSubItem 对象被点击:

You can use the ListView HitTest method. It returns a ListViewHitTestInfo object.
Its SubItem property gives you the ListViewSubItem object clicked:

可以使用 ListViewItem.SubItems.IndexOf() 方法.ListViewItem 和 SubItem 都在 ListViewHitTestInfo 对象中被引用.

The corresponding ColumnHeader object can be identified using the ListViewItem.SubItems.IndexOf() method. Both the ListViewItem and SubItem are referenced in the ListViewHitTestInfo object.

private void listView1_MouseDoubleClick(object sender, MouseEventArgs e)
{
    var hitInfo = listView1.HitTest(e.Location);
    if (hitInfo.SubItem == null || string.IsNullOrEmpty(hitInfo.SubItem.Text)) return;

    int subItemIndex = hitInfo.Item.SubItems.IndexOf(hitInfo.SubItem);
    var column = listView1.Columns[subItemIndex];

    // Do whatever you need to do with the SubItem text
    string result = ProcessSubItemText(hitInfo.SubItem.Text, column);
    Clipboard.SetText(result, TextDataFormat.UnicodeText);
}