我遇到了同样的问题，但有不同的解决方案.请注意，我已更新到 VS 2015 Update 1，但问题仍然存在.

I had the same problem but a different solution. Please note I updated to VS 2015 Update 1 and the problem is still there.

在以前版本的 VS 中，启动调试会自动触发调试模式下的构建.但在 VS2015 中却没有.

In previous edition of VS starting debug automatically triggered a build in debug mode. But with VS2015 it does not.

因此，如果您的上次构建处于发布模式，并且您尝试调试，则断点将不起作用.

So if your last build was in release mode, and you try debugging, breakpoint won't work.

您必须手动先在调试模式下构建，然后再开始调试.