dynamic might simplify a limited number of reflection scenarios (where you know the member-name up front, but there is no interface) - in particular, it might help with generic operators (although other answers exist) - but other than the generic operators trick, there is little crossover with generics.

Generics allow you to know (at compile time) about the type you are working with - conversely, dynamic doesn't care about the type. In particular - generics allow you to specify and prove a number of conditions about a type - i.e. it might implement some interface, or have a public parameterless constructor. dynamic doesn't help with either: it doesn't support interfaces, and worse than simply not caring about interfaces, it means that we can't even see explicit interface implementations with dynamic.

Additionally, dynamic is really a special case of object, so boxing comes into play, but with a vengence.

In reality, you should limit your use of dynamic to a few cases:

• COM interop
• DLR interop
• maybe some light duck typing
• maybe some generic operators

For all other cases, generics and regular C# are the way to go.