Don不使用调试变体输出！构建一个发布 apk。您可以通过转至菜单生成 - >生成已签名的APK，在Android Studio中执行此操作。或者通过执行./gradlew assembleRelease，如果您已经正确配置了在构建文件中的签名。

I Want to upload my apk to google play store.but its Show me error like this.

**You uploaded a debuggable APK. For security reasons you need to disable debugging before it can be published in Google Play**

and than i searched for this and i receive suggetion to change the android:debuggable="false" in manifast.xml.

I changed like this

manifast.xml

 <application
    android:allowBackup="true"
    android:debuggable="false"
    android:icon="@mipmap/ic_launcher"
    android:label="Concall"
    android:screenOrientation="portrait"
    android:theme="@style/AppTheme" >

and in my build.grable(Module)

android {
buildTypes {
    debug {
        debuggable false
    }
}

1.is the enough for upload Apk to google play store?

2.if i pick up apk from my project folder(app>>build>>output>>apk>>apk-debug.apk) after this change than after it will able to upload in google play store??

i need to know this thing Thanks in advance.

Don't use the debug variant output! Build a release apk. You can do that in Android Studio by going to the menu Build -> Generate Signed APK. Or by executing ./gradlew assembleRelease if you have properly configured signing in the build file.