应用程序'MACHINE / WEBROOT / APPHOST / MYAPP /物理根为'D：\home\site\admin\'的ADMIN'无法使用命令行'dotnet .\MyWeb.dll'启动进程，错误代码='0x80004005：80008081。

Application 'MACHINE/WEBROOT/APPHOST/MYAPP/ADMIN' with physical root 'D:\home\site\admin\' failed to start process with commandline 'dotnet .\MyWeb.dll', ErrorCode = '0x80004005 : 80008081.

看来，ASP.NET 4.5上的虚拟应用程序目标是由 AspNetCoreModule $ c服务的$ c>模块。您可以按以下方式修改ASP.NET 4.5应用程序中的 web.config 文件：

It seems that your virtual application targets on ASP.NET 4.5 is served by the AspNetCoreModule module. You could modify the web.config file under your ASP.NET 4.5 application as follows:

<configuration>
  <system.webServer>
    <handlers>
      <remove name="aspNetCore"/> <!--add this line-->
    </handlers>
  </system.webServer>
</configuration>

您可以关注的详细信息 ASP.NET配置文件的层次结构和继承。另外，您可以遵循类似的问题。

Details you could follow ASP.NET Configuration File Hierarchy and Inheritance. Also, you could follow this similar issue.